Beneficial loss

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Beneficial metabolic phenotypes caused by loss-of-function APOC3 mutations.

1. Gagné SE, Larson MG, Pimstone SN et al. A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study. Clin Genet 1999: 55 (6): 450–454. 2. Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations inPCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006: 354 (12): 1264–1272. 3...

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Tolerance and loss of beneficial effect during migraine prophylaxis: clinical considerations.

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ژورنال

عنوان ژورنال: Nature Reviews Immunology

سال: 2007

ISSN: 1474-1733,1474-1741

DOI: 10.1038/nri2083